Cytoplasmic+Transfer


 * Cytoplasmic transfer**: A technique in which cytoplasm from a donor egg is drawn into a pipette containing a single sperm from the male partner, after which that donated cytoplasm and the sperm are injected into the patient's egg.

Pasted from <[|http://www.pbs.org/wgbh/nova/baby/glossary.html#artificial]>

Cytoplasmic transfer From Wikipedia, the free encyclopedia JCytoplasmic transfer is an [|assisted reproductive technology] (ART), fertility technique whereby [|cytoplasm] from a donor egg is injected into an egg with compromised [|mitochondria]. The resulting egg is then [|fertilized] with [|sperm] and [|implanted] in a [|womb], usually that of the woman who provided the recipient egg and [|nuclear DNA]. Candidates Cytoplasmic transfer was created to aid women who experience infertility due to deficient or damaged mitochondria, contained within an egg's cytoplasm. Deficient mitochondria can lead to recurrent [|implantation] failure, high levels of [|embryo] fragmentation and overall poor embryo development. The incidence of compromised mitochondria increases with [|advanced maternal age], thought to occur near the age of thirty-five. Consequently, it has been found advantageous for young women to donate cytoplasm to older women, creating rejuvenated eggs. This is particularly desirable for couples or women who wish to genetically contribute to any resulting embryo, given cytoplasmic transfer does not interfere with the primary nuclear DNA input from the recipient egg. Risks Though cytoplasmic transfer does not involve the transfer of nuclear DNA, there may still be a small amount of [|mitochondrial DNA] present from the donor. Children conceived through this process occasionally test positive for genetic material from three parents. It is therefore arguably the first example of [|germ line] genetic modification (manipulation that affects future generations) of humans. Because of the chance for mitochondrial DNA transfer, the embryo may also be exposed to numerous diseases connected with mitochondrial DNA such as [|diabetes], [|Lou Gehrig's disease], and pervasive [|developmental disorders]. There is much concern associated with the potential transfer of mitochondrial DNA and its unknown interaction with the foreign DNA of the recipient egg. There is also no data as to the health of maturing children conceived through cytoplasmic transfer, the first successful birth having occurred in 1997 at [|Saint Barnabas Medical Center] in [|Livingston, New Jersey] as a result of procedure performed by [|The Institute for Reproductive Medicine and Science]. [|[1]] Pasted from <[]>